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Philip Hykin, A Toby Prevost, Sobha Sivaprasad, Joana C Vasconcelos, Caroline Murphy, Joanna Kelly, Jayashree Ramu, Abualbishr Alshreef, Laura Flight, Rebekah Pennington, Barry Hounsome, Ellen Lever, Andrew Metry, Edith Poku, Yit Yang, Simon P Harding, Andrew Lotery, Usha Chakravarthy & John Brazier.

Philip Hykin ^1,2,*, A Toby Prevost ³, Sobha Sivaprasad ^1,2, Joana C Vasconcelos ³, Caroline Murphy ⁴, Joanna Kelly ⁴, Jayashree Ramu ¹, Abualbishr Alshreef ⁵, Laura Flight ⁵, Rebekah Pennington ⁵, Barry Hounsome ^†, Ellen Lever ⁴, Andrew Metry ⁵, Edith Poku ⁵, Yit Yang ⁶, Simon P Harding ⁷, Andrew Lotery ⁸, Usha Chakravarthy ⁹, John Brazier ⁵

¹ National Institute for Health Research Moorfields Biomedical Research Centre, London, UK
² Institute of Ophthalmology, University College London, London, UK
³ Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, UK
⁴ King’s Clinical Trials Unit at King’s Health Partners, King’s College London, London, UK
⁵ School of Health and Related Research, University of Sheffield, Sheffield, UK
⁶ The Eye Infirmary, New Cross Hospital, Wolverhampton, UK
⁷ Eye and Vision Science, University of Liverpool, and St Paul’s Eye Unit, Royal Liverpool University Hospitals, Liverpool, UK
⁸ Faculty of Medicine, University of Southampton, Southampton, UK
⁹ Department of Biomedical Sciences, Queen’s University Belfast, Belfast, UK
^* Corresponding author Email: philhykin@gmail.com

^† In memoriam

In memoriam

Declared competing interests of authors: Philip Hykin has received grants, personal fees and non-financial support from Bayer AG (Leverkusen, Germany), Novartis International AG (Basel, Switzerland) and Allergan plc (Dublin, Ireland). A Toby Prevost was a member of the National Institute for Health Research (NIHR) Public Health Research Committee (June 2014–June 2020) and is a member of the NIHR COVID Call (Recovery and Learning) Committee (June 2020–present); he has received a lecture fee from Bayer AG and a grant from Boehringer Ingelheim (Ingelheim, Germany). Sobha Sivaprasad is part of the NIHR Health Technology Assessment (HTA) Commissioning Board (31 July 2017–present) and has received personal fees and grants from Novartis International AG, Bayer AG, Allergan plc and Boehringer Ingelheim, personal fees from F. Hoffmann-La Roche AG (Basel, Switzerland), personal fees and non-financial support from Optos plc (Marlborough, MA, USA) and personal fees from Heidelberg Engineering Inc. (Franklin, MA, USA). Laura Flight has received grants from NIHR for her NIHR Doctoral Fellowship, Adaptive Design Clinical Trials and their Impact on the Economic Evaluation of Health Care Technologies (DRF-2015-08-013), and another NIHR project, Value-based Adaptive Clinical Trial Designs for Efficient Delivery of NIHR Research (NIHR130354). Rebekah Pennington has received research grants from F. Hoffmann-La Roche AG. Yit Yang has received personal fees and non-financial support from Novartis International AG, Bayer AG and personal fees from Allergan plc and F. Hoffmann-La Roche AG. Simon P Harding has received grants to his employer from the NIHR HTA Clinical Evaluation and Trials UK and F. Hoffmann-La Roche AG. Andrew Lotery has received travel support from Bayer AG, and personal fees from Novartis International AG and Allergan plc. Usha Chakravarthy has received grants from NIHR [for the Inhibit VEGF in Age-related choroidal Neovascularisation (IVAN) trial, 07/36/01], was part of the HTA Prioritisation Committee (2010–14) and has received personal fees from Allergan plc and Novartis International AG.