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This study concluded that a full trial is unlikely to be feasible mainly owing to the low proportion of patients eligible.

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Elizabeth Cook 1,*, Arabella Scantlebury 1, Alison Booth 1, Emma Turner 1, Arun Ranganathan 2, Almas Khan 3, Sashin Ahuja 4, Peter May 2, Amar Rangan 1, Jenny Roche 1, Elizabeth Coleman 1, Catherine Hilton 2, Belén Corbacho 1, Catherine Hewitt 1, Joy Adamson 1, David Torgerson 1, Catriona McDaid 1

1 York Trials Unit, Department of Health Sciences, University of York, York, UK
2 Barts Health NHS Trust, The Royal London Hospital, London, UK
3 Leeds Teaching Hospitals NHS Trust, Leeds General Infirmary, Leeds, UK
4 Cardiff & Vale University Health Board, University Hospital of Wales, Cardiff, UK
* Corresponding author Email: liz.cook@york.ac.uk

Declared competing interests of authors: Amar Rangan has received grants from the National Institute for Health Research, Orthopaedic Research UK (London, UK) and the European Commission (Horizon 2020), and grants and personal fees from DePuy Synthes Johnson & Johnson Medical Devices Ltd (Warsaw, IN, USA), all outside the submitted work. Catherine Hewitt is a member of the National Institute for Health Research Health Technology Assessment Commissioning Board (2015 to present). Joy Adamson is a member of a National Institute for Health Research Health Technology Assessment Commissioning Committee (2017 to present). David Torgerson has received grants from National Institute for Health Research during the conduct of the study; the Clinical Trials Unit is funded by the National Institute for Health Research. Catriona McDaid is a member of the National Institute for Health Research Health Technology Assessment and Efficacy and Mechanism Evaluation Editorial Board (2017 to present). She has also received funding from the British Orthopaedic Association (London, UK) to support the development of grant applications for orthopaedic trials.

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