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Alastair D Hay, Michael V Moore, Jodi Taylor, Nicholas Turner, Sian Noble, Christie Cabral, Jeremy Horwood, Vibhore Prasad, Kathryn Curtis, Brendan Delaney, Roger Damoiseaux, Jesús Domínguez, Archana Tapuria, Sue Harris, Paul Little, Andrew Lovering, Richard Morris, Kate Rowley, Annie Sadoo, Anne Schilder, Roderick Venekamp, Scott Wilkes & Vasa Curcin.

Alastair D Hay ^1,†,*, Michael V Moore ^2,†, Jodi Taylor ³, Nicholas Turner ³, Sian Noble ³, Christie Cabral ¹, Jeremy Horwood ¹, Vibhore Prasad ⁴, Kathryn Curtis ³, Brendan Delaney ⁵, Roger Damoiseaux ⁶, Jesús Domínguez ⁴, Archana Tapuria ⁴, Sue Harris ³, Paul Little ², Andrew Lovering ⁷, Richard Morris ³, Kate Rowley ³, Annie Sadoo ³, Anne Schilder ⁸, Roderick Venekamp ⁶, Scott Wilkes ⁹, Vasa Curcin ⁴

¹ Centre for Academic Primary Care, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
² Primary Care and Population Sciences, University of Southampton, Southampton, UK
³ Bristol Randomised Trials Collaboration, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
⁴ School of Population Health and Environmental Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, UK
⁵ Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK
⁶ Julius Center for Health Sciences and Primary Care & Department of Otorhinolaryngology, UMC Utrecht, Utrecht, the Netherlands
⁷ Department of Medical Microbiology, North Bristol NHS Trust, Bristol, UK
⁸ Ear Institute, University College London, London, UK
⁹ School of Medicine, University of Sunderland, Sunderland, UK
^* Corresponding author Email: alastair.hay@bristol.ac.uk

^† Joint lead authors

Joint lead authors

Declared competing interests of authors: Alastair D Hay is a member of the Efficacy and Mechanism Evaluation (EME) Funding Committee (2019–present), is a National Institute for Health Research (NIHR) Senior Investigator (NIHR200151) and is a member of the National Institute for Health and Care Excellence Common Infections Committee. Vibhore Prasad is a NIHR Academic Clinical Lecturer in General Practice (2019–present). Paul Little was a member of the NIHR Journals Library Board while Director of the Programme Grants for Applied Research (PGfAR) programme (2013–18). Anne Schilder is Director of the NIHR Biomedical Research Centre at University College London Hospitals NHS Foundation Trust and University College London Hearing Theme (London, UK) and is the National Specialty Lead of the NIHR Clinical Research Network Ear, Nose and Throat (ENT); in these roles, Anne Schilder advises companies in the hearing field on the design and delivery of clinical trials. Her evidENT research team at the University College London Ear Institute (London, UK) receives support from various funders, including NIHR, the European Union (EU) Horizon 2020 (Brussels, Belgium) and the Wellcome Trust (London, UK). Roderick Venekamp reports grants from the Netherlands Organisation for Health Research and Development (ZonMw; The Hague, the Netherlands) during the conduct of the study.