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This research programme identified risk factors, diagnostic biomarkers and patient preferences for treatment of prosthetic joint infection, and showed single-stage to be as good as and cheaper than two-stage revision.

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Ashley W Blom 1,2,*, Andrew D Beswick 2, Amanda Burston 2, Fran E Carroll 3, Kirsty Garfield 3,4, Rachael Gooberman-Hill 2, Shaun Harris 3,4, Setor K Kunutsor 1,2, Athene Lane 3,4, Erik Lenguerrand 2, Alasdair MacGowan 5, Charlotte Mallon 2, Andrew J Moore 2, Sian Noble 3, Cecily K Palmer 3,6, Ola Rolfson 2,7, Simon Strange 2, Michael R Whitehouse 1,2

1 National Institute for Health and Care Research Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, UK
2 Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
3 Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
4 Bristol Randomised Trials Collaboration, University of Bristol, Bristol, UK
5 Department of Medical Microbiology, Southmead Hospital, Bristol, UK
6 National Institute for Health and Care Research Applied Research Collaboration West (NIHR ARC West), University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK
7 Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
* Corresponding author Email: Ashley.Blom@bristol.ac.uk

Declared competing interests of authors: Ashley W Blom is a co-applicant on a grant from Stryker Corporation (Kalamazoo, MI, USA) for investigating the outcome of the Triathlon total knee replacement. He is a member of the National Joint Registry lot 2 contract (statistical analysis) team and a member of the National Institute for Health and Care Research (NIHR) Bristol Biomedical Research Centre. Erik Lenguerrand is also a member of the National Joint Registry lot 2 contract (statistical analysis) team. Ola Rolfson reports grants from Stryker Corporation, Pfizer Inc. (New York, NY, USA) and LINK Sweden AB (Åkersberga, Sweden) outside the submitted work. Michael R Whitehouse undertakes teaching on basic sciences for orthopaedic trainees preparing for the Fellowship of the Royal College of Surgeons; his institution receives market-rate payment for this teaching from Heraeus (Hanau, Germany). He undertakes teaching on total hip replacement for orthopaedic consultants and trainees; his institution receives market-rate payment for this teaching from DePuy Synthes (Raynham, MA, USA). He is a co-applicant on a grant from Stryker Corporation investigating the outcome of the Triathlon total knee replacement. He is a member of the National Joint Registry lot 2 contract (statistical analysis) team. He is NIHR Clinical Research Network West of England lead for Trauma and Emergencies, a member of the NIHR Bristol Biomedical Research Centre and principal investigator on two NIHR Health Technology Assessment grants (NIHR129011 and NIHR127849).

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