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This trial found that a 12-month group-based exercise and behavioural maintenance intervention improved lower limb physical function over 24 months.

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Afroditi Stathi 1,*, Janet Withall 4, Colin J Greaves 1, Janice L Thompson 1, Gordon Taylor 2, Antonieta Medina-Lara 2, Colin Green 2, Tristan Snowsill 2, Heidi Johansen-Berg 3, James Bilzon 4, Selena Gray 5, Rosina Cross 4, Max J Western 4, Jolanthe L de Koning 4, Peter Ladlow 6, Jessica C Bollen 2, Sarah J Moorlock 1, Jack M Guralnik 7, W Jack Rejeski 8, Melvyn Hillsdon 9, Kenneth R Fox 10

1 School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK
2 University of Exeter Medical School, St Luke’s Campus, Exeter, UK
3 Wellcome Centre for Integrative Neuroimaging, Oxford Centre for Functional MRI of the Brain, Wellcome Centre for Integrative Neuroimaging, John Radcliffe Hospital, University of Oxford, Oxford, UK
4 Department for Health, University of Bath, Bath, UK
5 Faculty of Health and Applied Sciences, University of the West of England Bristol, Bristol, UK
6 Academic Department of Military Rehabilitation, Defence Medical Rehabilitation Centre, Loughborough, UK
7 Department of Epidemiology and Public Health, University of Maryland, School of Medicine, Baltimore, MD, USA
8 Department of Health and Exercise Science, Wake Forest University, Worrell Professional Centre, Winston-Salem, NC, USA
9 College of Life and Environmental Sciences, University of Exeter, Exeter, UK
10 Centre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, Bristol, UK
* Corresponding author Email: A.Stathi@bham.ac.uk

Declared competing interests of authors: Colin Green was a member of the National Institute for Health and Care Research (NIHR) Health Technology Assessment (HTA) General Committee (2019–20). Colin J Greaves was a member of the NIHR HTA Disease Prevention Panel (2009–13). Antonieta Medina-Lara is a member of the NIHR HTA Committee (2020–present); the South West for Research for Patient Benefit Programme (2021–present); and the NIHR Global Health Units & Groups Research Funding Committee (2021–present). Heidi Johansen-Berg is funded by the Wellcome Trust (110027/Z/15/Z) and the Oxford NIHR Biomedical Research Centre.

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