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Although orlistat, sibutramine and rimonabant are all effective at reducing weight and body mass index and, compared with placebo, are all cost-effective, both sibutramine and rimonabant have been withdrawn because of safety concerns relating to potential treatment-induced fatal adverse events.
1 School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK
2 Departments of Cardiovascular Sciences and Health Sciences, University of Leicester, Leicester, UK
* Corresponding author Email: r.m.ara@sheffield.ac.uk
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