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This trial found that in delivering cancer chemotherapy, centrally inserted totally implantable venous access devices had lower complication rates than centrally inserted tunnelled catheters, and lower rates than peripherally inserted central catheters.

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Olivia Wu 1,*, Elaine McCartney 2, Robert Heggie 1, Evi Germeni 1, James Paul 2, Eileen Soulis 2, Susan Dillon 2, Caoimhe Ryan 3, Moira Sim 1, Judith Dixon-Hughes 2, Roshan Agarwal 4, Andrew Bodenham 5, Tobias Menne 6, Brian Jones 7, Jonathan Moss 8

1 Health Economics and Health Technology Assessment (HEHTA), Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK
2 Cancer Research UK Glasgow Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK
3 School of Social Sciences, University of Dundee, Dundee, UK
4 Oncology, Northampton General Hospital, Northampton, UK
5 Intensive Care, Leeds Teaching Hospitals, Leeds, UK
6 Haematology, Newcastle Freeman Hospital, Newcastle upon Tyne, UK
7 Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
8 Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
* Corresponding author Email: olivia.wu@glasgow.ac.uk

Declared competing interests of authors: Olivia Wu is the deputy chairperson of the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) General Funding Board (2020 to present) and was a committee member of the NIHR HTA General Funding Board (2016–19). Jonathan Moss received payment from Smith Medical Inc. (Minneapolis, MN, USA) to run a PORTs training course annually. Brian Jones has received payment for lectures from Pfizer Inc. (New York, NY, USA) and Merck Sharp & Dohme Corp. (Kenilworth, NJ, USA), and payment for attendance at the advisory board from the Menarini Group (Florence, Italy). Brian Jones owns shares in Novartis AG (Basel, Switzerland) and Gilead Sciences Inc. (Foster City, CA, USA), and is a member of the Scottish Medicines Consortium. Moira Sim reports having a post funded by NIHR during the conduct of the study.

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