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This study confirmed evidence was lacking about the optimal mode of delivery for women in preterm labour and found agreement that a trial should be conducted.

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Jane E Norman 1,*, Julia Lawton 2, Sarah J Stock 2, Dimitrios Siassakos 3, John Norrie 4, Nina Hallowell 5, Sushila Chowdhry 6, Ruth I Hart 2, David Odd 7, Jane Brewin 8, Lucy Culshaw 9, Caroline Lee-Davey 9, Hannah Tebbutt 10, Sonia Whyte 11

1 Faculty of Health Sciences, University of Bristol, Bristol, UK
2 Usher Institute, University of Edinburgh, Edinburgh, UK
3 Institute for Women’s Health, University College London, London, UK
4 Edinburgh Clinical Trials Unit, University of Edinburgh, Edinburgh, UK
5 Ethox Centre and Wellcome Centre for Ethics & Humanities, Nuffield Department of Population Health, University of Oxford, Oxford, UK
6 School of Health Sciences, University of Dundee, Dundee, UK
7 Division of Population Medicine, School of Medicine, University of Cardiff, Cardiff, UK
8 Tommy’s, London, UK
9 Bliss, London, UK
10 , Edinburgh, UK
11 Tommy’s Centre for Maternal and Fetal Health, MRC Centre for Maternal and Fetal Health, University of Edinburgh, Edinburgh, UK
* Corresponding author Email: jane.e.norman@bristol.ac.uk

Declared competing interests of authors: Jane E Norman has received grants from government and charitable bodies for research into understanding the mechanisms of term and preterm labour and understanding treatments, including research funding from the National Institute for Health Research (NIHR) (references 17/63/08 and 16/151/01). Within the last 3 years, Jane E Norman has acted on a Data Safety and Monitoring Board for a study involving a preterm birth therapeutic agent for GlaxoSmithKline plc (Brentford, UK) and has provided consultancy for a small pharma company on drugs to alter labour progress. In addition, Jane E Norman was a member of the Health Technology Assessment (HTA) Maternal Neonatal and Child Health Panel (2013–18) and was a member of the HTA and Efficacy and Mechanism Evaluation (EME) Editorial Board from 2012 to 2014. Julia Lawton was a member of HTA Obesity Themed Call Board (2010) and HTA General Committee (2018–19). Sarah J Stock reports grants from the NIHR HTA programme during the conduct of the study and declares being a member of the NIHR HTA General Committee (2016–21). In addition, Sarah J Stock received other research funding from the NIHR (reference 14/32/01), Wellcome Trust (London, UK) (reference 209560/Z/17/Z) and Chief Scientist Office (London, UK) during the course of the study. Dimitrios Siassakos reports grants from the NIHR HTA Research for Patient Benefit (reference PB-PG-0817-20046) and HTA programme (references 16/16/06, NIHR127818 and PR-PRU-1217-21202) during the conduct of the study. In addition, Dimitrios Siassakos reports grants from the NIHR Biomedical Research Centre at University College London Hospitals (London, UK) and non-financial support from Wellcome Engineering and Physical Sciences Research Council Centre for Interventional and Surgical Sciences (London, UK) outside the submitted work. Last, Dimitrios Siassakos was a member of the HTA Maternal, Neonatal and Child Health Panel (2017–18), HTA Prioritisation Committee C (Mental Health, Women and Children’s Health) (2017–20) and HTA Prioritisation Committee B (In Hospital) (2017–21). John Norrie reports grants from the University of Edinburgh (Edinburgh, UK) during the conduct of the study, and is a past and present member of the following: HTA Commissioning Sub-Board (Expressions of Interest) (2012–16), NIHR Clinical Trials Unit Standing Advisory Committee (2017–present), NIHR HTA and EME Editorial Boards (2014–19), Pre-Exposure Prophylaxis Impact Review Panel (2017–present), EME Strategy Advisory Committee (2019–present), EME – Funding Committee Members (2019–present), EME Funding Committee Sub-Group Remit and Competitiveness Check (2019–present), HTA General Committee (2016–19), HTA Funding Committee Policy Group (formerly Clinical Study Group) (2016–19) and HTA Commissioning Committee (2010–16). In addition, John Norrie acted as a NIHR Journals Library Editor between 2014 and 2019. Nina Hallowell is a member of the Wellcome Centre for Ethics and Humanities (Oxford, UK), which is supported by funding from the Wellcome Trust (grant number 203132).

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